Spring Antibody History

Practical Immunohistochemistry (IHC) Tools: Spring’s focus on tissue pathology led to the advent of the first rabbit monoclonal antibodies developed for use in IHC. Many of these “SP” or Spring proprietary clones have subsequently risen to international prominence in their respective areas – the most notable being the SP1 Estrogen Receptor antibody. SP1 is recommended as the gold standard by leading breast cancer pathologists/agencies and is distributed around the world.

Rabbit Monoclonal antibodies such as Estrogen Receptor (clone SP1), c-erbB-2/HER-2 (clone SP3) and Ki67 (clone SP6) are excellent industry examples in the use of standardized immunohistochemical procedures providing superior antibody sensitivity and specificity. Spring’s high affinity antibodies are developed to increase lab efficiency and test flexibility, and can be used across a variety of applications. Spring Antibody Product types include:

Rabbit Monoclonal Antibodies
Spring Rabbit Monoclonals (RMAb) combine the best high affinity antibodies from rabbits with the unique high specificity of monoclonals. Spring's Rabbit Monoclonal antibodies portfolio has demonstrated high sensitivity when used in Immunohistochemistry (IHC) paraffin-embedded tissues (FFPE).

Rabbit Polyclonal Antibodies
Antibodies produced by rabbits are known to have higher affinity than antibodies raised in mice. Spring's Rabbit Polyclonals are antigen affinity purified and show higher specificity compared with many commercially available rabbit polyclonals.

Mouse Monoclonal Antibodies
In addition to Spring's unique rabbit monoclonals and large selection of rabbit polyclonals optimized for use in IHC, Spring has also developed many mouse monoclonals using a conventional hybridoma technology to fulfill customer needs.

Antibody Applications:

These include: