AKT-1/PKB (phospho S473)
Catalog Number: E13451
The serine threonine protein kinase encoded by the AKT-1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT-1 and the related AKT-2 are activated by platelet derived growth factor. The activation is rapid and specific. In the developing nervous system AKT is a critical mediator of growth factor induced neuronal survival. Survival factors can suppress apoptosis in a transcription independent manner by activating the serine/threonine kinase AKT-1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene (referenced from entrez gene). The antibody labels activated AKT-1 that is phosphorylated at 473 serine residue.
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Product Details
| Catalog Number | E13451 |
| Host | Rabbit |
| Clone Name | na |
| Dilution | Ready-to-use |
| Application | IHC-P |
| Species Reactivity | Hu |
| Quantity | 7ml |
| Regulatory Rating | Research Use Only |
| Entrez | 207 |
| Storage Requirement | 2-8°C |
| Isotype | Rabbit IgG |
| Immunogen | A synthetic peptide derived from the region of human AKT-1 that contains phosphorylated site of serine 473. |
| Target MW | 60 kDa |
| Formulation | 7 ml prediluted antibody in a 50mM Tris/1% BSA buffer pH 7.6 with 0.1% sodium azide. |
| Price | $209.00 |
