KOC/L523S
Catalog Number: E18314
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
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Product Details
| Catalog Number | E18314 |
| Host | Rabbit |
| Clone Name | na |
| Dilution | 1:100 |
| Application | IHC-P |
| Species Reactivity | Hu |
| Quantity | 1ml |
| Regulatory Rating | Research Use Only |
| Entrez | 10643 |
| Storage Requirement | 2-8°C |
| Isotype | Rabbit IgG |
| Immunogen | A synthetic peptide corresponding to internal region of human KOC/L523S. |
| Target MW | 70 kDa |
| Formulation | 1 ml rabbit antibody in 10mM PBS, pH 7.4 with BSA and Sodium Azide. |
| Price | $379.00 |
