alpha-1-Antitrypsin
Catalog Number: E3440
alpha-1-antitrypsin (alpha-1-AT) exists in a number of genetic variants. MM variant is the most common. Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
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Product Details
| Catalog Number | E3440 |
| Host | Rabbit |
| Clone Name | na |
| Dilution | 1:100 |
| Application | IHC-P |
| Species Reactivity | Hu |
| Quantity | 0.1ml |
| Regulatory Rating | Research Use Only |
| Entrez | 5265 |
| Storage Requirement | 2-8°C |
| Isotype | Rabbit IgG |
| Immunogen | Purified human alpha-1-antitrypsin. |
| Target MW | 52 kDa |
| Formulation | 0.1 ml immunogen affinity purified immunoglobulin from rabbit serum in 10mM PBS, pH 7.4 with BSA and sodium azide. |
| Price | $35.00 |
