MMP-15/MT2-MMP
Catalog Number: E4121
MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.
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Product Details
| Catalog Number | E4121 |
| Host | Rabbit |
| Clone Name | na |
| Dilution | Ready-to-use |
| Application | IHC-P |
| Species Reactivity | Hu, Ms |
| Quantity | 7ml |
| Regulatory Rating | Research Use Only |
| Entrez | 4324 |
| Storage Requirement | 2-8°C |
| Isotype | Rabbit IgG |
| Immunogen | A synthetic peptide from the catalytic domain of mouse MMP-15/MT2-MMP protein. |
| Target MW | 62 kDa and 66 kDa |
| Formulation | 7 ml prediluted antibody in a 50mM Tris/1% BSA buffer pH 7.6 with 0.1% sodium azide. |
| Price | $169.00 |
