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BRAF V600E

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Human colon carcinoma with V600E mutation stained with anti-BRAF V600E antibody
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Human colon carcinoma with V600E mutation stained with anti-BRAF V600E antibody

Human colon carcinoma with V600E mutation stained with anti-BRAF V600E antibody

QuantityCatalog No.VolumeDilutionPrice
E192900.1ml50$499.00
E192920.5ml50$2,000.00
E192941.0ml50$4,000.00

Serine/threonine-protein kinase B-raf (BRAF) is a member of the Raf family. BRAF mutations are frequent in benign and malignant human tumors. BRAF V600E mutation accounts for the vast majority of BRAF alterations and the mutation induces a conformational change of the activation segment leading to a constitutive kinase activity of BRAF and consecutive phosphorylation of downstream targets. BRAF V600E mutation have been detected in melanoma, papillary thyroid carcinoma, pleomorphic xanthoastrocytomas, Langerhans cell histiocytosis, borderline ovarian cancer, ganglioglioma, colorectal carcinoma, and pilocytic astrocytoma.

Product Details:

  • TechnologyMouse Monoclonal
  • Clone NameVE1
  • ApplicationIHC-P, WB
  • Species Reactivity
  •   TestedHu
  •   Predicted by homology
  • IsotypeMouse IgG2a
  • ImmunogenSynthetic peptide representing the BRAF V600E mutated amino acid sequence from amino acid 596 to 606 (GLATEKSRWSG)
  • Cellular LocalizationCytoplasm
  • Control TissueColon Carcinoma with BRAF V600E mutation
  • Regulatory RatingResearch Use Only (RUO)
  • Entrez673
  • Storage Requirement2-8°C
  • Target Molecular Weight95 kDa
  • FormulationRefer to Data Sheet