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S100 beta (Clone SP127) Rabbit Monoclonal


S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 is highly expressed in melanocyte, nerve cells, and their tumors. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.

Human tonsil stained with anti-S100 beta antibody (Cat# M4274)

 
 

Claudin-1 (Clone SP128) Rabbit Monoclonal


Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.

Human hepatocellular carcinoma stained with anti-Claudin-1 antibody (Cat# M4284)

 
 

EZH2 (Clone SP129) Rabbit Monoclonal


KMT6/Enhancer of zeste homologue 2 (EZH2) is a histone lysine methyl transferase associated with transcriptional repression. It is a component of the polycomb repressive complexes PRC2 and PRC3. The PRC2 complex catalyses histone H3 K27 trimethylation. EZH2 is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. EZH2 is highly expressed in follicular T-cells and in a variety of tumors such as lymphoma, breast and prostate.

Human prostate adenocarcinoma stained with anti-EZH2 antibody (Cat#M4294)

 
 

Ku80 (Clone SP130) Rabbit Monoclonal


X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells, and reduce drug resistance.

Human tonsil stained with anti-Ku80 antibody (Cat# M4304)

 
 

Luteinizing Hormone (LH) (Clone SP132) Rabbit Monoclonal


Luteinizing hormone (LH, also known as lutropin) is a tropic hormone which modulates the secretory activity of other endocrine glands. It is produced in the anterior hypophysis of the pituitary gland. The glycoprotein hormone, LH, like follicle stimulating hormone and thyroid stimulating hormone, is composed of a common alpha-subunit but also a specific beta-subunit, which characterizes each of these hormones.

Human pituitary stained with anti-Luteinizing Hormone (LH) antibody (Cat#4324)

 
 

FoxP1 (Clone SP133) Rabbit Monoclonal


Forkhead box protein P1 (FOXP1) is a transcriptional repressor that plays an important role in the development of the brain and lung in mammals. The gene encoding this protein may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene. It is essential transcriptional regulator of B cell development. PAX5/FOXP1 translocation t(9;3)(p13;p14.1) is found in acute lymphoblastic leukemia. FOXP1 is positive in subset of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphomas.

Human tonsil stained with anti-FoxP1 antibody (Cat# M4334)

 
 

Fn14 (Clone SP134) Rabbit Monoclonal


Fn14/Tweak receptor/CD266/TNFRSF12A, tumor necrosis factor receptor superfamily member 12A, is the receptor for Tweak, a member of the TNF family and was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins.

Human renal cell carcinoma stained with anti-Fn14 antibody (Cat# 4344)

 
 

Keratin 18 (Clone SP135) Rabbit Monoclonal


Cytokeratin 18 (CK18) is an acidic keratin found primarily in simple epithelium and is present in a majority of adenocarcniomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with a basic keratin cytokeratin 8.

Human liver stained with anti-Keratin 18 antibody (Cat# M4354)