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Human tonsil stained with anti-IDO-1 antibody

IDO-1 (SP260)

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is an enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-D-kynurenine. High levels of IDO are seen in antigen presenting cells and some tumor cells.

Human ovarian adenocarcinoma stained with anti-B7-H3 antibody

B7-H3/CD276 (SP265)

B7-H3 (also known as CD276) is a membrane protein that participates in the regulation of T-cellmediated immune response. B7-H3 can activate both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells. High levels of B7-H3 are seen in antigen presenting cells, some tumor cells, and tumor vasculature. It is the target of anticancer immunotherapy.

Human tonsil stained with anti-CD33 antibody.

CD33 (SP266)

Myeloid cell surface antigen CD33 is an adhesion molecule of myelomonocytic-derived cells. It is expressed by monocytes, macrophages, granulocyte precursors, premyelocytes, myeloid blast, and some tumors such as acute myeloid leukemia and acute monocytic leukemia.