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Human tonsil stained with anti-IDO-1 antibody

IDO-1 (SP260)




Indoleamine-pyrrole 2,3-dioxygenase (IDO) is an enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-D-kynurenine. High levels of IDO are seen in antigen presenting cells and some tumor cells.




Human ovarian adenocarcinoma stained with anti-B7-H3 antibody

B7-H3/CD276 (SP265)




B7-H3 (also known as CD276) is a membrane protein that participates in the regulation of T-cellmediated immune response. B7-H3 can activate both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells. High levels of B7-H3 are seen in antigen presenting cells, some tumor cells, and tumor vasculature. It is the target of anticancer immunotherapy.




Human tonsil stained with anti-CD33 antibody.

CD33 (SP266)




Myeloid cell surface antigen CD33 is an adhesion molecule of myelomonocytic-derived cells. It is expressed by monocytes, macrophages, granulocyte precursors, premyelocytes, myeloid blast, and some tumors such as acute myeloid leukemia and acute monocytic leukemia.




M567 (SOX10)_Melanoma.jpg

SOX-10




SOX-10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. SOX-10 is predominantly found in oligodendrocytes, peripheral glial cells, melanocytes and adult neural crest stem cell populations. SOX-10 is up-regulated in melanoma, glioma, Schwannoma, neurofibroma, pheochromocytoma, and lung carcinoid tumor.




M569 (PD-1)_Tonsil.jpg

PD-1/CD279




Programmed cell death protein 1 (PD-1), as known as CD279, is a member of CD28/CTLA-4 family of T cell regulators. It is expressed on the surface of activated T cells, B cells, and macrophages as a negative regulator for immune responses. The binding of PD-1 with its ligands PDL1 and PDL2 on T cells, monocytes, and some tumor cells can trigger inhibition of T-cell function.