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E1931 (EPCAM-ICD) Colon Adenocarcinoma.jpg

EpCAM-ICD




Epithelial cellular adhesion molecule (Ep-CAM), also known as epithelial specific antigen (ESA), is an antigen for epithelial differentiation and is expressed on most simple epithelia and their carcinomas.




Human placenta stained with anti-PD-L1 antibody

PD-L1/CD274 (SP142)




Programmed cell death 1 ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is mainly expressed in antigen presenting cells, activated T and B cells, placenta, and some tumors such as melanoma, diffuse large B-cell lymphoma, and carcinoma of the lung, colon, and rectum. *Call for pricing on additional product sizes




Human placenta stained with anti-galectin-1 antibody

Galectin-1 (SP247)


Human placenta stained with anti-galectin-1 antibody

Galectin-1 (gal-1) is expressed intracellularly and extracellularly by various normal and pathological tissues. It shows a wide range of biological activity such as apoptosis, cell proliferation and cell differentiation. Gal-1 is overexpressed in endothelial cells of different human tumors, tumor cells, and extracellular matrix. It binds its ligands such as beta-galactoside and a wide array of complex carbohydrates to regulate immune responses.




Human tonsil stained with anti-TCL1A antibod

TCL1A (SP248)


Human tonsil stained with anti-TCL1A antibod

T-cell leukemia/lymphoma protein 1A (TCL1) is a member of the TCL1 family and is mainly expressed in the T-cells, immature thymocytes, activated peripheral lymphocytes, and subset of B-cells. TCL1 enhances the phosphorylation and activation of AKT1, AKT2 and AKT3 and promote cell proliferation. Rearrangements at the TCL1 locus are associated with T-cell leukemia/ lymphoma.




Human skin stained with anti-C4.4A/LYPD3 antibody

C4.4A/LYPD3 (SP250)


Human skin stained with anti-C4.4A/LYPD3 antibody

C4.4a is a membrane bound protein associated with cell migration, wound healing, cell-matrix interaction, and tumor progression. It is overexpressed in some squamous cell carcinoma of lung, head and neck, majority of primary and metastatic transitional cell carcinomas (TCCs), ovarian cancer, colorectal cancer, prostate cancer, and breast cancer.




Human tonsil stained with anti-CD68 antibody

CD68 (SP251)


Human tonsil stained with anti-CD68 antibody

CD68 is an intracellular glycoprotein mainly expressed on macrophages and monocytes. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML) (M1-M5 types), and granulocytic sarcoma.