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Human lung carcinoma stained with anti-EGFR (del) antibody

Epidermal Growth Factor Receptor (EGFR) (E746-A750del) (SP111)


Human lung carcinoma stained with anti-EGFR (del) antibody

EGFR is a transmembrane tyrosine kinase that belongs to the HER/erbB protein family. Somatic mutations in the tyrosine kinase domain of EGFR are present in a subset of lung adenocarcinoma. Two types of mutations account for approximately 90% of mutant cases: a specific point mutation L858R which occurs in exon 21 and short in-frame deletions in exon 19. A common lesion in exon 19 is the deletion of E746-A750, although other variants can also occur.




Human lung carcinoma stained with anti-EGFR (L858R) antibody

Epidermal Growth Factor Receptor (EGFR) (L858R) (SP125)


Human lung carcinoma stained with anti-EGFR (L858R) antibody

EGFR is a transmembrane tyrosine kinase of HER/erbB protein family. EGFR somatic mutations such as L858R in exon 21 and short in-frame deletion of E746-A750 in exon 19 are present in a subset of lung adenocarcinoma.




Human prostate adenocarcinoma stained with anti-PTEN antibody

PTEN (SP170)




Phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN) is a tumor suppressor and a member in the PI3K/PTEN/AKT pathway. PTEN is a phosphatase with dual specificity to slow cell growth and antagonize the growth promoting activities from HER protein kinases. The defects of PTEN, mostly around the C-terminus of PTEN, have been implicated in many human cancers and diseases. Therefore, antibody to the N terminus will not be able to detect most of the PTEN protein loss.




Human tonsil stained with anti-cleaved PTEN (D301) antibody

Cleaved PTEN (D301) (SP227)


Human tonsil stained with anti-cleaved PTEN (D301) antibody

Phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN) is a tumor suppressor and can be cleaved by caspase-3 at multiple sites (D301, D371, D375, and D384) during apoptosis. The generation of cleaved PTEN (D301) is an indicator of apoptosis.




Human endometrial adenocarcinoma stained with anti-FBXW7 antibody

FBXW7 (SP237)


Human endometrial adenocarcinoma stained with anti-FBXW7 antibody

F-box/WD repeat-containing protein 7 (Fbxw7) is part of an ubiquitin-protein ligase complex. The complex ubiquitinates and degrades several important oncogenes such as mTOR, MYC, AURKA, JUN, and NOTCH1. Fbxw7 cooperates with PTEN for tumor suppression and is widely expressed in many normal tissues. The loss of fbxw7 is associated with malignant progression in a variety of tumors, including carcinoma of colorectum, lung, stomach, bile duct, endometrium, pancreas, breast and glioblastoma.




Human tonsil stained with anti-PU.1 antibody

PU.1 (SP238)


Human tonsil stained with anti-PU.1 antibody

PU.1 is a transcription factor of the Ets family and activates target genes through the purine-rich PU-box. PU.1 plays an important role for the differentiation of myeloid cells and early B cell lymphocytes. PU.1 is overexpressed in some B cell lymphoma, Hodgkin, and non- Hodgkin lymphoma.




Human tonsil stained with anti-CD79b antibody

CD79b (SP240)


Human tonsil stained with anti-CD79b antibody

Cluster of Differentiation 79b (CD79b) is a B lymphocyte antigen receptor and present as a multimeric complex consisting of the antigen-specific component and surface immunoglobulin (Ig). It is overexpressed in some B cell lymphomas such as non-Hodgkin lymphoma, Burkitt’s lymphoma, and acute lymphoblastic leukemia.




Human Lung adenocarcinoma stained with anti-MUC-4 antibody

MUC-4 (SP241)


Human Lung adenocarcinoma stained with anti-MUC-4 antibody

Mucin-4 (MUC-4) is a membrane-bound mucin with a very large glycosylated extracellular domain and a short cytoplasmic domain. It plays an important role in cell proliferation and differentiation of epithelial cells. It is expressed in a subset of normal epithelia and is overexpressed in many types of carcinoma such as lung, breast, digestive tract, biliary tract, colon, cervix and pancreas.




Human prostate adenocarcinoma stained with anti-AR (C-term) antibody

Androgen Receptor (AR) (C-term) (SP242)




Androgen receptor (AR) is a receptor for the androgenic hormones testosterone or dihydrotestosterone and it is a member of the steroid superfamily of ligand-dependent transcription factors. In the absence of androgen, the unligated AR mainly locates in cytoplasm, but translocates to the nucleus upon binding to androgen. Truncated AR variants with loss of C-terminus are common in prostate cancer.