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Ku80 (SP130)

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Western Blot analysis of HeLa cell lysate with Ku80 antibody
Human tonsil stained with anti-Ku80 antibody
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Human tonsil stained with anti-Ku80 antibody

Human tonsil stained with anti-Ku80 antibody

QuantityCatalog No.VolumeDilutionPrice
M43000.1ml100$196.00
M43020.5ml100$403.00
m43041.0ml100$620.00
M43017.0ml $351.00

X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells, and reduce drug resistance.

Product Specification Sheets:

M430(Ku80)_RUO_D.pdf

Material Safety Data Sheets:

US: Primary Abs_sb047_2.0.pdf

INTL/EU: Primary abs_sb047EU_2.0.pdf

Product Details:

  • TechnologyRabbit Monoclonal
  • Clone NameSP130
  • ApplicationIHC-P, WB
  • Species Reactivity
  •   TestedHu
  •   Predicted by homologyRt, Bv
  • IsotypeRabbit IgG
  • ImmunogenSynthetic peptide corresponding to an internal region of human Ku80 protein.
  • Cellular LocalizationNucleus
  • Control TissueTonsil
  • Regulatory RatingResearch Use Only (RUO)
  • Entrez7520
  • Storage Requirement2-8°C
  • Target Molecular Weight86 kDa
  • FormulationRefer to Data Sheet